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11 eggs collected and only 2 made it to blastocyst. Is our lab bad or is that just what happens?

Between cycles and big decisions · started Aug 25, 2026 · 5 replies · 420 views

August 25, 2026, 9:36 pm#1

Some of you will remember me from the day 6 symptoms thread in July. The test was negative, in the end. I'm alright, or I'm functioning, which I'm counting as the same thing for now.

Follow-up was last week and I've come out of it fixated on one thing I didn't think about at the time. Our collection in June got 11 eggs, which everyone said was great. Then it was 9 mature, then 6 fertilised (we did ICSI), then on day 3 they said "all six looking good", and then on day 5 the call was two blastocysts, both frozen, and that was it. Two. From eleven. One is now used and gone, so we have one left and a decision to make about whether to transfer it or do another collection first.

What I keep circling is whether losing four "looking good" embryos between day 3 and day 5 is normal, or whether it's the lab. My sister-in-law had 8 eggs at a different clinic and got 5 blastocysts, and I can't stop doing that comparison. The consultant said our numbers were "within the normal range" but didn't say what the range IS. Would a day 3 transfer have saved some of them? Is it my eggs or his sperm, and how would you even know? And at what point does anyone actually say the lab is the problem, because they're never going to say it about themselves are they.

I'm 33, no diagnosis on my side, mild male factor on his, first ever cycle. Sorry this is long. I have been holding it in for a week.

August 26, 2026, 8:52 am#2

Niamh, I'm so sorry about July. I remember your thread and I hoped.

Some numbers for your collection of comparisons, from the other end of the age range. My big collection a couple of years ago was 21 eggs, the freeze-all one, and everyone was thrilled, and it came to four blastocysts. Four from twenty-one. The two fresh cycles since, at 41, were 7 eggs and one blastocyst each time, graded with a C in them that I chose not to think about, and a friend from my clinic's waiting room had 5 eggs and none reached day 5 at all, which is the outcome nobody mentions is possible. So two from eleven, at 33, sits very differently from where I'm standing, though I know that's no comfort when your sister-in-law got five from eight. Different people, different eggs, different weeks. That comparison will eat you if you let it.

August 26, 2026, 7:20 pm#3

Adding this month's data point since I'm literally in the middle of it. Collection on the 15th, 9 eggs, 7 mature, 5 fertilised, and on day 5 we had 3 blastocysts: transferred one fresh on the 20th, two in the freezer. Third cycle. My first two cycles were 7 eggs and 2 blasts, then 8 eggs and 1 blast, same clinic, same lab, same me. So three cycles of the same lab gave me 2, 1 and 3, which is the thing I'd gently say about your sister-in-law: one cycle is one roll, hers and yours.

I asked about day 3 last time, out of exactly your fear, and got a version of "we'd just be moving the drop-off into you". Didn't like it at the time. Believe it now.

August 28, 2026, 9:40 am#4

Niamh, I'm sorry about the result, and I'm glad you asked this here, because "within the normal range" is a phrase that deserves a range attached to it. General information follows; your own lab's figures and your own next step are for your clinic, who know your case.

The direct answer: two blastocysts from eleven eggs is an ordinary result, not a poor one, and the drop between day 3 and day 5 is where the biggest loss is expected. The arithmetic runs roughly like this. Of the eggs collected, typically 75 to 90 percent are mature; yours were 9 of 11, which is good. Of mature eggs, around 60 to 70 percent fertilise normally with ICSI; 6 of 9 is squarely in that band. And of normally fertilised eggs, roughly 30 to 50 percent reach the blastocyst stage by day 5 or 6, which from six gives an expected two or three. You got two. Louise's three cycles of 2, 1 and 3 from similar starting numbers are the same arithmetic with the ordinary variation on top; Mrs Okafor's four from twenty-one shows that a large collection does not scale the way people hope, and the cycle with none at all is the lower tail of the same distribution, more likely with age and fewer eggs but possible at any age.

On why "all six looking good" on day 3 became two: the embryo runs on the egg's stored machinery for the first two to three days, and its own genes only switch on at around the 8-cell stage, on about day 3. Embryos that look fine on day 3 and then stall are usually ones whose own genome could not sustain development once it took over, most often because of a chromosomal error carried from the egg or, less commonly, from the sperm. That is also the answer to whether a day 3 transfer would have saved them: it would not. An embryo that arrests in the dish on day 4 arrests in the womb on day 4. Transferring on day 3 does not add embryos, it removes information about which ones were viable, which is why most labs grow to blastocyst whenever there are enough embryos to justify it, and consider a day 3 transfer mainly when there are only one or two, to avoid reaching day 5 with nothing.

Eggs or sperm: the two stages point in different directions, loosely. A low fertilisation rate with ICSI points at sperm or egg activation problems; you had a normal one. Loss between day 3 and day 5 is more often egg-related, because the egg contributes the bulk of the chromosomal machinery, though severe sperm DNA damage can also show up as arrest after day 3. Mild male factor with a normal ICSI fertilisation rate would not, on its own, be my first suspect. At 33, a blastocyst rate of a third from normally fertilised eggs is unremarkable.

When the lab is the problem: the way to know is not one patient's numbers but the lab's. Embryology labs track their blastocyst formation rate per normally fertilised egg as a key performance indicator, and the international consensus benchmark most labs measure themselves against is around 40 percent, with anything much lower across many patients being a flag. You are entitled to ask your clinic what their figure is for your age group and how it compares with that benchmark, and a good lab will tell you. What a single cycle's two from six cannot tell you is whether the lab underperformed, because it sits comfortably inside the expected range. The site's guide to embryo grading sets out the whole week, the attrition at each step, and what the day 5 grades your two were given actually mean, which may help with the decision about the one that's left.

That decision, transfer the remaining blastocyst or collect again first, is a real one with reasonable arguments on both sides, and it depends on things I don't know: its grade, your reserve, your finances, and how you would feel with nothing in the freezer. Take the arithmetic above into that conversation and ask them to show you where your cycle sat in their own numbers. It is a fair question, and it is not an accusation.

August 29, 2026, 7:15 am#5

niamh_c said:

at what point does anyone actually say the lab is the problem

This was me after cycle two, convinced. I switched clinics after cycle three for other reasons and my numbers were, if anything, worse at the new one. Same eggs. Turns out the lab had been fine and I'd wanted somewhere to put it.

The one useful thing I did get from asking: the second clinic showed me their blastocyst rate for my age band without being defensive at all, and that told me more about them than the answer did.

September 10, 2026, 8:05 pm#6

Update, because you were all so kind. I emailed the clinic with the exact question, blastocyst rate per fertilised egg for women under 35, and asked how our cycle compared. They came back with a figure a bit above 40 percent for the lab and wrote, quite plainly, that our 2 from 6 was slightly below their average and within the range they'd expect for a first cycle, and that it wouldn't change their advice.

Somehow having the actual number has let the sister-in-law thing go. We're transferring the last one in October, grade 4BB, which I now know how to read. Not a prophecy. Thank you, all of you.